Biomarcadores metabólicos y su asociación con el deterioro de la filtración glomerular en adultos mayores
DOI:
https://doi.org/10.61616/rvdc.v7i2.1836Palavras-chave:
beta-2 microglobulina, edad avanzada, prevención, salud renalResumo
La carga de complicaciones renales está en aumento debido a la alta prevalencia de enfermedades no transmisibles presentes en la población global y la ausencia de herramientas diagnósticas precisas que evalúen el estado de filtración glomerular. Frente a esta situación, el presente estudio tuvo como finalidad analizar los biomarcadores metabólicos y su asociación con el deterioro de la filtración glomerular en adultos mayores. Se trató de una revisión sistemática descriptiva, la cual consideró la guía PRISMA 2020 como protocolo para la elaboración de la misma. Los artículos publicados entre 2021 y 2026 incluidos mediante criterios de elegibilidad fueron consultados en fuentes de alta pertinencia científica como PubMed, Embase y Scopus, con el apoyo de una estrategia de búsqueda combinada (AND y OR). Los resultados demostraron que la interleucina-10, la Molécula de lesión renal-1, la beta microglobulina y cistatina C se asocian con la función renal. Además, el cálculo de la CKD-EPI en conjunto con otros indicadores bioquímicos permiten revelar el estado de la filtración glomerular. Por último, el factor de necrosis tumoral alfa, la cistatina C, la creatinina sérica, la beta-microglobulina, la apolipoproteína M, la 3-metilglutarilcarnitina y el índice aterogénico del plasma presentan una asociación significativa con esta complicación. Se concluye que, el deterioro de la filtración glomerular se puede convertir en un problema controlable en la población envejecida si se opta por un estilo de vida óptimo junto a un monitoreo constante de la función renal.
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Copyright (c) 2026 René Aurelio Angulo Zuña, Nathaly Mayte Cruz Chiquito, Claudio Javier Gutiérrez Yoza, Adonis Jair Muñoz Garcia, Jenniffer Cañarte Murillo
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